ABC849

Anti-ZIP-1 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Zinc transporter ZIP1, Solute carrier family 39 member 1, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1, ZIP-1, hZIP1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human, mouse
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: Q9NY26
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SLC39A1(27173)

Description

Description générale

Zinc transporter ZIP1, also known as Solute carrier family 39 member 1 or Zinc-iron-regulated transporter-like or Zrt- and Irt-like protein 1 (ZIP-1 or hZIP1), and encoded by the gene name SLC39A1 or IRT1 or ZIP1 or ZIRTL, is responsible to the rapis uptake and accumulation of physiologically effective zinc in prostate cells. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to downregulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

Spécificité

This antibody is predicted to not cross-react with other ZIP family members.

Immunogène

Epitope: N-terminus

KLH-conjugated synthetic peptide corresponding to the N-terminus of human ZIP-1.

Application

Anti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected ZIP-1 in human kidney tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualité

Evaluated by Western Blotting in Mouse kidney tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ZIP-1 in Mouse kidney tissue lysate.

Description de la cible

~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable