559406

SB 328437

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

• Synonyme(s) : SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
• Formule empirique (notation de Hill): C₂₁H₁₈N₂O₅
• Numéro CAS: 247580-43-4
• Poids moléculaire : 378.38
• Numéro MDL: MFCD16618397
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• Clé InChI: VMFGCGRAIBLAFY-IBGZPJMESA-N

Description

Description générale

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of ¹²⁵I-eotaxin and ¹²⁵I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC₅₀ = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC₅₀ = 38, 35, and 20 nM, respectively).

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC₅₀ values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC₅₀ values: 32, 25, and 55 nM, respectively).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
CC chemokine receptor-3 (CCR3)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

White, J.R., et al. 2000. J. Biol. Chem.275, 36626.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable