537011
Prolyl Endopeptidase Inhibitor II
The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonyme(s) :
Prolyl Endopeptidase Inhibitor II, Z-PP-CHO
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About This Item
Formule empirique (notation de Hill) :
C18H22N2O4
Numéro CAS:
Poids moléculaire :
330.38
Code UNSPSC :
12352200
Produits recommandés
Niveau de qualité
Essai
≥97% (HPLC)
Forme
oil
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
protect from light
Couleur
colorless to off-white
Solubilité
DMSO: 10 mg/mL
DMF: soluble
ethyl acetate: soluble
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
Mouse brain prolylendooeotidase
Mouse brain prolylendooeotidase
Product does not compete with ATP.
Reversible: no
Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Standard Handling (A)
Séquence
Z-Pro-Pro-CHO
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Autres remarques
Fülöp, V., et al. 1998. Cell94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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