5.33796

Asparagine Endopeptidase Inhibitor, AENK

• Synonyme(s) : Asparagine Endopeptidase Inhibitor, AENK, Fmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
• Formule empirique (notation de Hill): C₃₃H₄₃N₇O₉
• Poids moléculaire : 681.74
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: water: 25 mg/mL
• Température de stockage: −20°C

Description

Description générale

An amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

An amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Actions biochimiques/physiologiques

Primary Target
AEP

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

Fmoc-Ala-Glu-Asn-Lys-NH2

Forme physique

Supplied as a TFA salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Zhang, Z., et al. 1999. Nat. Med.20, 1254.
Monoury, B., et al. 1998. Nat.396, 695.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable