5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

• Synonyme(s) : JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• Formule empirique (notation de Hill) : C₂₀H₂₃NO₃
• Numéro CAS: 409345-29-5
• Poids moléculaire : 325.40
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥98% (TLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 0.55 nM IC₅₀; 0.34 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white
• Solubilité: DMSO: 25 mM
• Température de stockage: 2-8°C

Description

Description générale

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (K_i = 0.34 nM; IC₅₀ = 0.55 nM). 400-fold more selective for mGlu₁ than for mGlu₅ and no interaction with mGlu₂, mGlu₃, mGlu₄, mGlu₆, AMPA or NMDA receptors (IC₅₀ >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

Actions biochimiques/physiologiques

Primary Target
mGlu₁

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany