481414

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem

The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonyme(s) : NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem, 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
• Formule empirique (notation de Hill) : C₁₅H₁₅NO₂S
• Numéro CAS: 113760-29-5
• Poids moléculaire : 273.35
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: ethanol: 10 mg/mL; DMSO: 50 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Description générale

A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser¹⁷⁷ and/or Ser¹⁸¹ residues in the kinase′s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC₅₀ = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Kim, B.H., et al. 2008. Mol. Pharmacol.73, 1309.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable