OK to freeze desiccated (hygroscopic) protect from light
Conditions d'expédition
wet ice
Température de stockage
−20°C
Description générale
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Irritant (B)
Forme physique
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Autres remarques
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015. Vassilev, L.T., et al. 2004. Science303, 844.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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