420305

K-252c

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC₅₀ = 2.45 µM) and protein kinase A (IC₅₀ = 25.7 µM).

• Synonyme(s) : K-252c
• Formule empirique (notation de Hill): C₂₀H₁₃N₃O
• Numéro CAS: 85753-43-1
• Poids moléculaire : 311.34
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white
• Solubilité: DMSO: 5 mg/mL; methanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
• Clé InChI: MEXUTNIFSHFQRG-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (IC₅₀ = 25.7 µM) and protein kinase C (IC₅₀ = 2.45 µM).

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC₅₀ = 2.45 µM) and protein kinase A (IC₅₀ = 25.7 µM).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKC

Product competes with ATP.

Reversible: yes

Target IC₅₀: 2.45 µM against protein kinase C

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Nakanishi, S., et al. 1986. J. Antibiot. 39, 1066.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H319
• Conseils de prudence: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable