401488

IKK-3 Inhibitor IX

The IKK-3 Inhibitor IX, also referenced under CAS 862812-98-4, controls the biological activity of IKK-3. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonyme(s) : IKK-3 Inhibitor IX, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
• Formule empirique (notation de Hill) : C₂₂H₁₉N₃O₅S₂
• Numéro CAS: 862812-98-4
• Poids moléculaire : 469.53
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: beige
• Solubilité: DMSO: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
• Clé InChI: LDTAHRLHGHFHKP-UHFFFAOYSA-N

Description

Description générale

A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC₅₀ = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC₅₀<50 µM) 1A2, 2D6, 2C9, and 3A4.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
IKK-3

Product competes with ATP.

Reversible: no

Target IC₅₀: 40 nM against IKK-3 (IKK-ε)

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett.16, 6236.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable