361555

GSK-3 Inhibitor XIII

The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : GSK-3 Inhibitor XIII, (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
• Formule empirique (notation de Hill): C₁₈H₁₅N₅
• Numéro CAS: 404828-08-6
• Poids moléculaire : 301.35
• Numéro MDL: MFCD16495817
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: [nH]1nc(cc1Nc2nc(nc4c2cccc4)c3ccccc3)C
• InChI: 1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
• Clé InChI: JYCUVOXSZBECAY-UHFFFAOYSA-N

Description

Description générale

A potent and ATP-competitive inhibitor of GSK-3 (K_i = 24 nM).

An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K_i of 24 nM.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
GSK-3

Product does not compete with ATP.

Reversible: no

Target K_i: 24 nM against GSK-3

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Pierce, A.C., et al. 2005. J. Med. Chem.48, 1278.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1