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345996

Sigma-Aldrich

Glial Fibrillary Acidic Protein, Human Brain

Synonyme(s) :

GFAP

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About This Item

Code UNSPSC :
12352202

Pureté

≥90% (SDS-PAGE)

Niveau de qualité

Forme

lyophilized

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Solubilité

distilled water: 1 mg/mL

Conditions d'expédition

ambient

Température de stockage

−20°C

Description générale

Native, glial fibrillary acidic protein purified from human brain. Main component of the intermediate filaments in astrocytes. Marker of sclerotic plaques in gliosed brain.
Native, glial fibrillary acidic protein purified from human brain. Marker of sclerotic plaques in brain and gliosed brain. Isolated from normal human brain. A component of astroglial intermediate filaments. Forms glial filaments in astrocytes in the central nervous system and in some Schwann cells in peripheral nerves.



Molecular Weight: 43,000-49,000

Avertissement

Toxicity: Standard Handling (A)

Forme physique

Lyophilized from 16 mM Sodium Bicarbonate, pH 8.5.

Notes préparatoires

Prepared from tissues of individuals that have been shown by certified tests to be negative for HbsAg, HIV-1 and HIV-2 antibodies, HCV, and syphilis.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Anderiva, M., et al. 2001. Glia35, 189.
Masood, K., et al. 1993. J. Neurochem. 61, 160.
Liem, R.K., and Hutchison, S.B. 1982. Biochemistry21, 3221.
Dahl, D. 1973. Brain Res.57, 343.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Ronald J Ellis et al.
Journal of neurology and psychology, 9(1) (2022-01-01)
Astrocytes become activated with certain infections, and this might alter the brain to trigger or worsen depressed mood. Indeed, astrocytes are chronically activated in people with HIV infection (PWH), who are much more frequently depressed than people without HIV (PWoH).
Mohamed B Abou-Donia et al.
Brain sciences, 10(9) (2020-09-10)
For the past 30 years, there has been a lack of objective tools for diagnosing Gulf War Illness (GWI), which is largely characterized by central nervous system (CNS) symptoms emerging from 1991 Gulf War (GW) veterans. In a recent preliminary
John E Buonora et al.
Frontiers in neurology, 6, 68-68 (2015-04-15)
Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include the development of plasma biomarkers for assessing neurologic injury, monitoring pathogenesis, and predicting vulnerability for the development of untoward neurologic outcomes. While several biomarker proteins have
Mohamed B Abou-Donia et al.
Brain sciences, 11(2) (2021-01-28)
Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has
Sharmilee Gnanapavan et al.
PloS one, 8(8), e70019-e70019 (2013-08-13)
Lamotrigine trial in SPMS was a randomised control trial to assess whether partial blockade of sodium channels has a neuroprotective effect. The current study was an additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting

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