344036-M

cFMS Receptor Tyrosine Kinase Inhibitor

The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : cFMS Receptor Tyrosine Kinase Inhibitor, 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
• Formule empirique (notation de Hill): C₂₀H₂₂N₄O₃
• Numéro CAS: 870483-87-7
• Poids moléculaire : 366.41
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 25 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
• Clé InChI: MYQAUKPBNJWPIE-UHFFFAOYSA-N

Description

Description générale

A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC₅₀ = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC₅₀ >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.

A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC₅₀ = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC₅₀ >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.

Actions biochimiques/physiologiques

Primary Target
CFMS

Target IC₅₀: 30 nM against cFMS kinase activity

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA102, 16078.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable