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324895

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eIF-2α Inhibitor, Salubrinal

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.

Synonyme(s) :

eIF-2α Inhibitor, Salubrinal, Sal

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About This Item

Formule empirique (notation de Hill):
C21H17Cl3N4OS
Numéro CAS:
304475-63-6
Poids moléculaire :
479.81
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥90% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

beige

Solubilité

DMSO: 10 mg/mL

Conditions d'expédition

wet ice

Température de stockage

−20°C

Description générale

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380)). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.

Actions biochimiques/physiologiques

Cell permeable: yes
Primary Target
elF-2α
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM preventing HSV replication both in Vero cells.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Boyce, M., et al. 2005. Science307, 935.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

YongYao Xu et al.
PloS one, 17(7), e0271656-e0271656 (2022-07-29)
Inflammatory signaling induces barrier dysfunction in retinal-pigmented epithelium (RPE) cells and plays a role in the pathology of age-related macular degeneration (AMD). We studied the role of Zn flux from the endoplasmic reticulum (ER) to the cytoplasm via Zip7 during
Ziwei Zhang et al.
Molecular nutrition & food research, 66(5), e2100791-e2100791 (2021-12-31)
To investigate the role of endoplasmic reticulum stress (ERS)-induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L. (POL) extract, a medicinal herb with anti-inflammatory, antioxidant, immune-regulating, and antitumor properties, in vitro and in vivo.
Ting Zhu et al.
Veterinary research, 52(1), 148-148 (2021-12-22)
Viruses have evolved multiple strategies to manipulate their host's translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α). In this study, we show that global protein synthesis
Ai-Ling Tian et al.
Cell death & disease, 12(1), 6-6 (2021-01-09)
The integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the

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