219399

Cathepsin D Substrate I

Useful as a substrate for the determination of cathepsin D activity.

• Synonyme(s) : Cathepsin D Substrate I, Bz-RGFFP-4-MeOβNA, HCl
• Formule empirique (notation de Hill) : C₄₉H₅₅N₉O₇ · xHCl
• Poids moléculaire : 882.02 (free base basis)
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Fluorescence: λ_ex ~345 nm; λ_em ~425 nm
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A useful substrate for colorimetric or fluorometric assay of cathepsin D activity. Cathepsin D hydrolyzes the Phe-Phe bond. Dipeptidyl aminopeptidase II is required to free the 4-methoxy-β-naphthylamine (4MβNA). Excitation max: ~345 nm; emission max: ~425 nm.

Useful as a substrate for the determination of cathepsin D activity. Suitable for either colorimetric or fluorometric assay. Cathepsin D hydrolyzes the Phe-Phe bond. Requires dipeptidyl aminopeptidase II to free 4-methoxy-β-naphthylamine (4MeOβNA).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Substrate for the determination of cathepsin D activity

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Séquence

Bz-Arg-Gly-Phe-Phe-Pro-4MeOβNA, HCl

Autres remarques

Takahashi, T., and Tang, J. 1981. Methods Enzymol.80, 565.
Smith, R.E., and Van Frank, R.M. 1975. in Lysosomes in Biology and Pathology4 (Dingle, J.T., and Dean, R.T., eds.) p. 193, American Elsevier, Holland.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable