205536

Cadein1

A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system.

• Synonyme(s) : Cadein1
• Formule empirique (notation de Hill): C₃₃H₄₈F₂INO₂
• Poids moléculaire : 655.64
• Numéro MDL: MFCD32671841
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: FC1=CC=CC(F)=C1C[N+](CC2)=C(C3=C2C=C(C(OC)=C3)OC)CCCCCCCCCCCCCCC.[I-]

Description

Description générale

A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HeLa, HT29, and SW620 (viability &lt19 %; 4-6 µM Cadein1 for 24 h), while exhibiting much reduced potency in MMR^-/p53⁺ (RKO and HCT116), MMR^-/p53^- (DLD-1 and HCT116-E6), and MMR⁺/p53⁺ (HCT116-Ch3 and HEK293) cancer cultures (viability = 40 to 92%; 4 µM Cadein1 for 24 h).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Jang, E.R., et al. 2010. J. Biol. Chem.285, 2986.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable