196871
BAY 11-7082
InSolution, ≥95%, Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α
Synonyme(s) :
InSolution BAY 11-7082
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About This Item
Formule empirique (notation de Hill):
C10H9NO2S
Poids moléculaire :
207.25
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥95% (HPLC)
Forme
liquid
Puissance
10 μM IC50
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
protect from light
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Description générale
Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
TNF-α-inducible phosphorylation of IκBα
TNF-α-inducible phosphorylation of IκBα
Product does not compete with ATP.
Reversible: no
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Irritant (B)
Forme physique
Supplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
Autres remarques
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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