N-terminal GST-tagged, recombinant human full length MAP Kinase 2
Product Source: Expressed in E. coli
Application
Research Category Metabolism
Inflammation & Immunology
Research Sub Category Obesity
Metabolic Disorders
Osteoporosis
Arthritis
Actions biochimiques/physiologiques
Protein Target: MAPK2
Target Sub-Family: CMGC
Qualité
routinely evaluated by phosphorylation of MBP substrate
Forme physique
Glutathione agarose affinity chromatography
Stockage et stabilité
6 months at -20°C
Autres remarques
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Although the translational function of tRNA has long been established, extra translational functions of tRNA are still being discovered. We previously developed a computational method to systematically predict new tRNA-protein complexes and experimentally validated six candidate proteins, including the mitogen-activated
Targeting KRAS mutant tumors through inhibition of individual downstream pathways has had limited clinical success. Here we report that RAF inhibitors exhibit little efficacy in KRAS mutant tumors. In combination drug screens, MEK and PI3K inhibitors synergized with pan-RAF inhibitors
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