116815-M

Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt

A cell-permeable cAMP analog that binds cAMP-receptor proteins.

• Synonyme(s) : Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt, Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
• Formule empirique (notation de Hill): C₁₀H₁₁N₅O₅PS · 4C₆H₁₆N
• Numéro CAS: 71774-13-5
• Poids moléculaire : 753.06
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: crystalline solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: water: 20 mg/mL
• Température de stockage: −20°C

Description

Description générale

A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.

A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λ_max = 258 nm; ε_max = 15,000 M^-1cm-1 (pH 7..0).

Note: 10 µmol = 4.47 mg.

Actions biochimiques/physiologiques

Primary Target
cAMP-receptor proteins

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun.182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch.420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem.110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable