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07-892

Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody

Name: Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody
Brand: MM

Upstate^®, from rabbit

Synonyme(s) :

PTK2B, Proline-rich tyrosine kinase 2, Focal adhesion kinase 2, FADK2, Cell adhesion kinase beta, RAFTK, Calcium-dependent tyrosine kinase, CADTK

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A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

polyclonal

Species reactivity:

human, rat

Application:

ICC, WB

Citations:

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Propriétés

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_004103.3, NM_173174.1, NM_173175.1, NM_173176.1

UniProt accession no.

Q14289

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr402)

Gene Information

human ... PTK2B(2185)

Description

General description

115 kDa

Immunogen

Peptide corresponding to amino acid region encompassing the human and rat phospho-Pyk2/CAKβ/FAK2 (Tyr402).

Application

Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Pyk2 (Tyr402) in RIPA lysate of Pyk2 transfected CEF cells

This Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody is validated for use in WB, IC for the detection of phospho-Pyk2/CAKβ/FAK2 (Tyr402).

Biochem/physiol Actions

Pyk2 phosphorylated on tyrosine residue 402

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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1 of 1

Cet article	07-832	06-543	05-1139
Sigma-Aldrich 07-892 Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody	Sigma-Aldrich 07-832 Anti-phospho-FAK (Tyr861) Antibody	Sigma-Aldrich 06-543 Anti-FAK Antibody	Sigma-Aldrich 05-1139 Anti-Focal Adhesion Kinase Antibody, clone BLAb2H7
species reactivity human, rat	species reactivity chicken, human, mouse	species reactivity human, hamster, mouse, rat	species reactivity human, mouse, rat, chicken
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone polyclonal	clone polyclonal	clone polyclonal	clone BLAb2H7, monoclonal
Gene Information human ... PTK2B(2185)	Gene Information human ... PTK2(5747)	Gene Information human ... PTK2(5747)	Gene Information chicken ... Ptk2(396416) human ... PTK2(5747) mouse ... Ptk2(14083) rat ... Ptk2(25614)
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in wet ice

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Differential signaling by the focal adhesion kinase and cell adhesion kinase beta.

M D Schaller et al.

The Journal of biological chemistry, 272(40), 25319-25325 (1997-10-06)

pp125(FAK) and CAKbeta/Pyk2/CadTK/RAFTK are related protein-tyrosine kinases. It is therefore of interest whether CAKbeta shares some of the properties of pp125(FAK). Using recombinant glutathione S-transferase fusion proteins, we show that the C-terminal domains of both proteins bind paxillin in vitro.

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Monika Raab et al.

Nature communications, 8, 16001-16001 (2017-07-13)

Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell

Numéro d'article de commerce international

Référence	GTIN
07-892	04053252731129

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