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05-1416

Sigma-Aldrich

Anti-CD45 Antibody, clone IBL-5/25

clone IBL-5/25, from rat

Synonyme(s) :

CD45 associated protein, CD45-associated protein, Lymphocyte phosphatase-associated phosphoprotein, PTPRC-associated protein, protein tyrosine phosphatase, receptor type, C-associated protein, protein tyrosine phosphatase, receptor type, c

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rat

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

IBL-5/25, monoclonal

Espèces réactives

mouse

Technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

Isotype

IgG

Numéro d'accès NCBI

NP_002829.2

Numéro d'accès UniProt

Q14761

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Ptprc(19264)

Catégories apparentées

Description générale

CD45 is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells; its substrates are unknown. Interestingly, it associates with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45.

Spécificité

Reactivity with other species has not been determined.
This antibody reacts with all isoforms of mouse CD45 which is expressed on all haematopoietic cells except erythrocytes.
FUSION PARTNER: SP2/0 myeloma cell line

Immunogène

Mouse lymph node cells.

Application

Anti-CD45 Antibody, clone IBL-5/25 is an antibody against CD45 for use in FC, IH.
Flow Cytometry Analysis: A previous lot detected CD45, clone IBL-5/25 in mouse peripheral blood lymphocytes

Qualité

Evaluated by Immunohistochemistry in mouse colon tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected CD45 in mouse colon tissue.

Description de la cible

Approx. 147 kDa

Liaison

Replaces: CBL1326

Forme physique

Format: Purified
Purified rat monoclonal IgG in phosphate buffered saline containing 10 mM sodium azide.

Stockage et stabilité

Store at 2-8°C for 12 months from date of receipt.

Remarque sur l'analyse

Control
Mouse colon tissue

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Aura R Garrison et al.
Nature communications, 15(1), 1722-1722 (2024-02-27)
Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV. Most efforts have focused on targeting the viral glycoproteins. However, glycoproteins are poorly conserved among viral
Jorge Santini-González et al.
Frontiers in endocrinology, 13, 989815-989815 (2022-12-13)
There is a critical need for therapeutic approaches that combine renewable sources of replacement beta cells with localized immunomodulation to counter recurrence of autoimmunity in type 1 diabetes (T1D). However, there are few examples of animal models to study such
Aleksandra Vukojicic et al.
Cell reports, 29(10), 3087-3100 (2019-12-05)
Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood. Similarly, the molecular mechanisms by which gene mutations cause dysfunction and elimination of
Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea.
Menardo, Julien, et al.
Antioxidants & Redox Signaling, 16, 263-274 (2012)
Laura A Marlow et al.
The Journal of clinical endocrinology and metabolism, 103(9), 3169-3182 (2018-05-31)
To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% of these have been proven to be either duplicates of existing thyroid lines or even nonthyroid-derived lines or are not derived from humans at
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