05-1144
Anti-Talin Antibody, CT, clone TD77
clone TD77, from mouse
Synonyme(s) :
talin 1
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
TD77, monoclonal
Espèces réactives
chicken, human, mouse
Technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
Isotype
IgG1
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
chicken ... Tln1(395194)
human ... TLN1(7094)
mouse ... Tln1(21894)
Description générale
Talin consisting of a 47-kDa N-terminal head domain (residues 1-433) and a 190-kDa
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
Spécificité
Expected cross-reactivity in mouse and chicken.
Recognizes Human Talin, and cross reacts with Mouse and chicken Talin. The epitope recognized by this antibody is located within the C-terminal region of the protein (residues 2269-2541), which also contains an F-actin binding site homologous to that in the yeast actin-binding protein SIa2p.
Application
Detect Talin using this Anti-Talin Antibody, C-terminus, clone TD77 validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Talin in human GI track tissue.
Qualité
Evaluated by Western Blot in Jurkat cell lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
Description de la cible
270 kDa
Liaison
Replaces: MAB3264
Forme physique
Format: Purified
Purified from Protein A Sepharose™ chromatography
Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PBS pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.
Stockage et stabilité
Maintain between 2 and 8°C for 1 year after date of receipt.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
Sepharose is a trademark of Cytiva
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Michèle Moes et al.
The Journal of biological chemistry, 282(23), 17280-17288 (2007-04-14)
Talin1 is a large cytoskeletal protein that links integrins to actin filaments through two distinct integrin binding sites, one present in the talin head domain (IBS1) necessary for integrin activation and a second (IBS2) that we have previously mapped to
Andreas Wortmann et al.
The Journal of biological chemistry, 286(49), 42303-42315 (2011-10-14)
Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment. Recently it has been recognized that another SFK substrate, CUB-domain-containing protein 1 (CDCP1), is differentially phosphorylated during these events. However, the
Yekaterina B Khotskaya et al.
Molecular carcinogenesis, 53(12), 1011-1026 (2013-09-04)
Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it decreases
Michael C Schmid et al.
Nature communications, 13(1), 1768-1768 (2022-04-03)
Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate angiogenesis, immune suppression and tumor progression. Chemokines, cytokines and interleukins
Mayra Álvarez-Santos et al.
Journal of cellular biochemistry, 117(10), 2385-2396 (2016-03-13)
The extracellular domains of some membrane proteins can be shed from the cell. A similar phenomenon occurs with β1 integrins (α1β1 and α2β1) in guinea pig. The putative role of β1 integrin subunit alterations due to shedding in airway smooth
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