N-903

Nordiazepam-d₅ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₅D₅H₆ClN₂O
• Numéro CAS: 65891-80-7
• Poids moléculaire : 275.74
• Numéro CE : 200-659-6
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• Concentration: 100 μg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: [2H]c1c([2H])c([2H])c(c([2H])c1[2H])C2=NCC(=O)Nc3ccc(Cl)cc23
• InChI: 1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)/i1D,2D,3D,4D,5D
• Clé InChI: AKPLHCDWDRPJGD-RALIUCGRSA-N

Description

Description générale

Nordiazepam is a benzodiazepine prescribed for treatment of anxiety and panic attacks. This stable-labeled internal standard is suited for quantitation of nordiazepam levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis or isotope dilution methods. Nordiazepam is also a primary urinary metabolite of benzodiazepines diazepam and chlrodiazepoxide.

Application

• Validation in psychoactive drug detection: A study developed a rapid UPLC-MS/MS method to detect multiple psychoactive substances, including Nordiazepam-d5, in post-mortem whole blood samples, highlighting its utility in forensic toxicology and drug monitoring (Barone et al., 2023).
• Application in neonatal drug exposure studies: Research employed liquid chromatography-high-resolution mass spectrometry, utilizing Nordiazepam-d5 as a reference, to determine venlafaxine exposure during gestation through neonatal hair analysis, illustrating its value in pediatric forensic investigations (Favretto et al., 2010).
• Detection in hair samples: The use of Nordiazepam-d5 was explored in a French study for the identification of benzodiazepine consumption in hair samples from drug addicts, demonstrating its effectiveness as a stable isotope-labeled standard for chronic exposure analysis (Vayssette et al., 1996).
• GC/MS analysis for benzodiazepine metabolites: A method was developed to analyze common benzodiazepine metabolites, including Nordiazepam, in urine, showcasing the application of Nordiazepam-d5 in creating more reliable and reproducible results in toxicological testing (West and Ritz, 1993).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup