L-010

Levomethorphan

vial of 10 mg, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₈H₂₅NO
• Numéro CAS: 125-70-2
• Poids moléculaire : 271.40
• Numéro CE : 204-751-7
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: solid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: vial of 10 mg
• Fabricant/nom de marque: Cerilliant^®
• Contrôle du médicament: USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3C)c2c1
• InChI: 1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1
• Clé InChI: MKXZASYAUGDDCJ-CGTJXYLNSA-N

Description

Description générale

A Certified Reference Material suitable for use in LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic analysis. Levomethorphan, the l-enantiomer of methorphan, is an opioid analgesic.

Application

• Enantioselective analysis of Levomethorphan: Development of a novel enantioselective high-performance liquid chromatography-mass spectrometry method for the differentiation of dextro- and levo-methorphan and their O-demethylated metabolites in human blood, applicable to post-mortem samples, highlighting its role in forensic toxicology (Jorbenadze et al., 2024).


• Quantitative determination in forensic samples: An enantioselective high-performance liquid chromatography-tandem mass spectrometry method was developed for the quantitative determination of methorphan and its O-demethylated metabolite in human blood, demonstrating Levomethorphan′s application as a reference standard in post-mortem forensic analysis (Lo Faro et al., 2023).


• Chiral analysis in human hair: A study on chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry, providing insights into their presence and metabolism in biological samples (Ji et al., 2022).


• Chiral purity determination: Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan using a dual selector system and quality by design methodology, enhancing the analytical capabilities for Levomethorphan (Krait et al., 2018).


• Metabolic study on chiral drugs: A metabolic study on the biochemical effects of chiral illegal drugs, including Levomethorphan, in rats using (1)H-NMR spectroscopy, contributing to understanding its biochemical behavior and potential impacts (Fukuhara et al., 2017).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable