860600P

Lyso SM (d18:1)

Avanti Research^™ - A Croda Brand 860600P, powder

• Synonyme(s) : Sphingosylphosphorylcholine
• Formule empirique (notation de Hill) : C₂₃H₄₉N₂O₅P
• Numéro CAS: 1670-26-4
• Poids moléculaire : 464.62
• Numéro MDL: MFCD02259287
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Forme: powder
• Conditionnement: pkg of 1 × 10 mg (860600P-10mg); pkg of 1 × 25 mg (860600P-25mg); pkg of 1 × 5 mg (860600P-5mg); pkg of 1 × 50 mg (860600P-50mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 860600P
• Type de lipide: sphingolipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O
• InChI: 1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
• Clé InChI: JLVSPVFPBBFMBE-HXSWCURESA-N

Description

Description générale

Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule.[1] This lysophospholipid is present in normal blood plasma, ascites and various tissues.[2]

Application

Lyso SM (d18:1) has been used:

• to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers[3]
• as an inhibitor of Ca²⁺ sensor calmodulin (CaM)[4]
• as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions[5]

Actions biochimiques/physiologiques

Lyso SM (d18:1) or sphingosylphosphorylcholine (SPC) is a lipid mediator that exhibits second messenger functions. It regulates ryanodine receptors (RyRs)[3] and releases Ca²⁺ from the sarco/endoplasmic reticulum. Lyso SM (d18:1) acts as an endogenous inhibitor of ubiquitous Ca²⁺ sensor calmodulin (CaM).[4]

Conditionnement

5 mL Amber Glass Screw Cap Vial (860600P-10mg)

5 mL Amber Glass Screw Cap Vial (860600P-25mg)

5 mL Amber Glass Screw Cap Vial (860600P-50mg)

5 mL Amber Glass Screw Cap Vial (860600P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable