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860540P

Avanti

C8 Glucosyl(β) Ceramide (d18:1/8:0)

Avanti Research™ - A Croda Brand 860540P, powder

Synonyme(s) :

D-glucosyl-β-1,1′-N-octanoyl-D-erythro-sphingosine

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About This Item

Formule empirique (notation de Hill):
C32H61NO8
Numéro CAS:
111956-47-9
Poids moléculaire :
587.83
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 5 mg (860540P-5mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 860540P

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

InChI

1S/C32H61NO8/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-26(35)25(33-28(36)22-20-17-8-6-4-2)24-40-32-31(39)30(38)29(37)27(23-34)41-32/h19,21,25-27,29-32,34-35,37-39H,3-18,20,22-24H2,1-2H3,(H,33,36)/b21-19+/t25-,26+,27?,29+,30?,31?,32+/m0/s1

Clé InChI

LCEXEEHGNKGJES-LSHBQEOXSA-N

Catégories apparentées

Description générale

C8 Glucosyl(β) Ceramide (d18:1/8:0) or D-glucosyl-β-1,1′-N-octanoyl-D-erythro-sphingosine is a short-chain glycosphingolipid (SC-GSL).

Application

C8 Glucosyl(β) Ceramide (d18:1/8:0) or D-glucosyl-β-1,1′-N-octanoyl-D-erythro-sphingosine has been used as a stock solution for the in vitro treatment of bacteria and to study the role of sphingolipids on pulmonary Pseudomonas aeruginosa infections in cystic fibrosis (CF). It may be suitable for the preparation of liposomes. It may also be used as a standard for the quantification of mitoxantrone in tumor by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Actions biochimiques/physiologiques

C8 Glucosyl(β) Ceramide (d18:1/8:0) or D-glucosyl-β-1,1′-N-octanoyl-D-erythro-sphingosine improves intracellular drug delivery in tumor cells. It is also considered as a drug uptake enhancer.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860540P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

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Consulter la Bibliothèque de documents

Lília R Cordeiro Pedrosa et al.
Biochimica et biophysica acta, 1848(8), 1656-1670 (2015-04-29)
Insufficient drug delivery into tumor cells limits the therapeutic efficacy of chemotherapy. Co-delivery of liposome-encapsulated drug and synthetic short-chain glycosphingolipids (SC-GSLs) significantly improved drug bioavailability by enhancing intracellular drug uptake. Investigating the mechanisms underlying this SC-GSL-mediated drug uptake enhancement is
Yifat Cohen et al.
PloS one, 8(12), e85519-e85519 (2014-01-07)
The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae. One such protein is Spf1, which
Lília R Cordeiro Pedrosa et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 207-219 (2015-05-20)
Mitoxantrone (MTO) is clinically used for treatment of various types of cancers providing an alternative for similarly active, but more toxic chemotherapeutic drugs such as anthracyclines. To further decrease its toxicity MTO was encapsulated into liposomes. Although liposomal drugs can
Aline Xavier da Silveira Dos Santos et al.
Molecular biology of the cell, 25(20), 3234-3246 (2014-08-22)
The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely unknown. We developed a systematic approach to uncover new players in the regulation of lipid homeostasis. Through an unbiased mass spectrometry-based lipidomic screening, we quantified hundreds of lipid species
Barbara Kovacic et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41(3), 1208-1218 (2017-04-21)
Cystic fibrosis (CF) is the most common autosomal-recessive disorder in western countries. Previous studies have demonstrated an important role of sphingolipids in the pathophysiology of cystic fibrosis. It has been shown that ceramide has a central role in various pulmonary
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