800715P
Avanti
N-P Serine PA
Avanti Research™ - A Croda Brand 800715P, powder
Synonyme(s) :
N-palmitoyl-serine phosphoric acid (ammonium salt)
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About This Item
Formule empirique (notation de Hill):
C19H44N3O7P
Numéro CAS:
Poids moléculaire :
457.54
Numéro MDL:
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Essai
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (800715P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 800715P
Type de lipide
phosphoglycerides
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor. [3][4] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][3][4][5] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1] N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium. [4][5]
N-palmitoyl serine phosphoric acid prevents human platelet aggregation, which is induced by 1-hexadecyl-2-lyso-sn-glycero-3-phosphate.[6]
Conditionnement
5 mL Amber Glass Screw Cap Vial (800715P-1mg)
Notes préparatoires
Product use: A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium. [5]An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[4] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
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Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids.
Bittman R, et al.
Journal of Lipid Research, 37(2), 391-398 (1996)
S B Hooks et al.
Molecular pharmacology, 53(2), 188-194 (1998-03-14)
Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry. We report
K Liliom et al.
Molecular pharmacology, 50(3), 616-623 (1996-09-01)
Lysophosphatidic acid is the best characterized member of a lipid mediator family with growth factor-like activities that act through a class of G protein-coupled plasma membrane receptors. In Xenopus laevis oocytes, lysophosphatidate activates at least two pharmacologically distinct receptor subtypes
R Bittman et al.
Journal of lipid research, 37(2), 391-398 (1996-02-01)
An improved synthesis of two lipid phosphoric acids, N-palmitoyl-L-serine phosphoric acid (NP-Ser-PA) and N-palmitoyl-L-tyrosine phosphoric acid (NP-Tyr-PA), from the benzyl esters of L-serine and L-tyrosine is described. The sequence of N-acylation, followed by phosphitylation with N, N-diisopropyl dibenzyl phosphoramidite, oxidation
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