QBD10119

Acid-dPEG^®₉-NHS ester

• Synonyme(s) : Polyethylene glycol
• Formule empirique (notation de Hill) : C₂₆H₄₅NO₁₅
• Poids moléculaire : 611.63
• Numéro MDL: MFCD28064339
• Code UNSPSC : 12352106
• ID de substance PubChem : 329823880
• Nomenclature NACRES : NA.22

Propriétés

• Essai: >90%
• Forme: solid or viscous liquid
• Pertinence de la réaction: reagent type: cross-linking reagent; reactivity: amine reactive
• Groupe fonctionnel: NHS ester; carboxylic acid
• Architecture des polymères: shape: linear; functionality: heterobifunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O
• InChI: 1S/C26H45NO15/c28-23-1-2-24(29)27(23)42-26(32)4-6-34-8-10-36-12-14-38-16-18-40-20-22-41-21-19-39-17-15-37-13-11-35-9-7-33-5-3-25(30)31/h1-22H2,(H,30,31)
• Clé InChI: BJOKQEMLFQBOQZ-UHFFFAOYSA-N

Description

Caractéristiques et avantages

Acid-dPEG^®₉-NHS ester is a unique heterobifunctional dPEG^® crosslinking product which allows conjugation to two different moieties, each containing free amines. Because the single molecular weight dPEG^® spacers contain an N-hydroxysuccinimide ester only on one end of the spacer, greater control of the conjugation reaction can be maintained. The free acid end of the spacer can be left unreacted to modify the surface properties of the molecule to which it is conjugated, or the free acid end can be activated and conjugated to a different group at a later time. The dPEG^® spacers provide precise spacing/distance control, and the dPEG^® itself provides the well-known benefits of increased water solubility; decreased immunogenicity; protection from proteolysis; increased hydrodynamic volume; and increased serum half-life.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable