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939439

Sigma-Aldrich

Hyaluronic acid hydrazide

Synonyme(s) :

ADH, Adipic acid dihydrazide, HA-ADH, Hyaluronic acid, Hyaluronic acid adipic dihydrazide

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About This Item

Formule linéaire :
(C14H23N3O10)n(C14H20N NaO11)m
Code UNSPSC :
12352200
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Forme

powder or chunks (or Fibers)

Niveau de qualité

100

Couleur

white to faint yellow-brown

Température de stockage

2-8°C

Chaîne SMILES 

OC1[C@H](O[*])[C@@H](C(NN)=O)O[C@H]([C@@H]1O)O[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]([C@@H]3O)[C@@H](C(O[Na])=O)O[C@H]([C@@H]3O)O[C@H]4[C@H](O)[C@@H](CO)O[C@H]([C@@H]4NC(C)=O)[*])[C@@H]2NC(C)=O

Catégories apparentées

Description générale

Hyaluronic acid hydrazide is a versatile and innovative functionalized natural polymer whereby the carboxylic acid moieties of hyaluronic acid are modified with mono- and polyfunctional hydrazides via controlled synthesis. Hyaluronic acid (HA), linear polysaccharide composed of alternating 1,4-linked units of 1,3-linnked glucuronic acid and N-acetylglucosamine, is a crucial component of the extracellular matrix (ECM). The hydrazide groups are highly reactive with aldehydes, leading to the formation of acyl hydrazone linkages. This is particularly useful for linking glycoproteins or carbohydrates in a site specific manner.

Application

  • Hyaluronic acid hydrazide can be used for a wide range of applications. By harnessing the controlled hydrazide modification of hyaluronic acid, this product can be used to create tailored solutions for various fields, including biomedical research, pharmaceuticals, and tissue engineering.
  • Applications include:
  • Developing new drug delivery systems such as prodrugs
  • Studying cell motility in 3D cell culture scaffolds
  • Engineering biocompatible scaffolds and hydrogels for areas such as cartilage tissue engineering
  • The hyaluronic acid hydrazide can also be used as an intermediate to synthesize other HA derivatives with various functional groups.

Caractéristiques et avantages

  • Biocompatible and biodegradable
  • Greater than 60% functionalized
  • Tailorable for tethering additional functional groups or biochemical moieties

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

914800

Hyaluronic acid methacrylate, Degree of substitution: 10% - 30%, Mw 170,000-250,000

914568

Hyaluronic acid methacrylate, average degree of substitution 35%, average Mw 55000

914304

Hyaluronic acid methacrylate, average degree of substitution 35%, average Mw 175000

924490

Hyaluronic acid methacrylate, Low Viscosity, Low Endotoxin, 0.2 um sterile filtered, 0.2 μm, sterile-filtered

924474

Hyaluronic Acid, Low Viscosity, Low endotoxin

935468

Aldehyde functionalized hyaluronic acid, Degree of functionalization ~40%

935441

Aldehyde functionalized hyaluronic acid, Degree of functionalization ~20%

935166

Hyaluronic acid, acid form, average Mw 25,000

Code de la classe de stockage

11 - Combustible Solids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCW4339

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Consulter la Bibliothèque de documents

G D Prestwich et al.
Journal of controlled release : official journal of the Controlled Release Society, 53(1-3), 93-103 (1998-09-19)
Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings for tissue engineering.

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