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934801

Sigma-Aldrich

Glycidol chitosan

Degree of functionalization > 80%

Synonyme(s) :

Dihydroxypropyl chitosan, Glycolchitosan, glycol chitosan

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About This Item

Formule linéaire :
[C9H17NO6]n [C8H13NO5]m
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.21

Niveau de qualité

100

Forme

powder or chunks (or fibres)

Couleur

white to off-white

Température de stockage

2-8°C

Description générale

Chitosan is a cationic biodgradable and biocompatible biopolymer that has been commonly used in many applications. The polymer chains are positively charged when disolved in aqueous solutions of pH<6.5. However, the biomedical applications of the positively charged chitosan are limited becuase it cannot be easily dissolved in aqueous media. Glycidol chitosan is a derivative of chitosan whereby hydrohilic glycidol is grafted onto the amino groups of chitosan to improve its solubility in a wider range of pH. It possesses many useful biological properties such as biocompatibility, biodegradability, and antimicrobial properties. It can also be further functionalized to induce photo and thermally crosslinkable properites and can be used as a precursor for hydrogel preparations that can be used in many biomedical applications.

Application

  • Hydrogels
  • Tissue engineering
  • Bioprinting
  • Drug delivery system

Caractéristiques et avantages

  • Naturally derived biopolymer
  • Cationic
  • Enhanced solubility
  • Tunable precursor material

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Chitosan chemistry and pharmaceutical perspectives
Kumar MR
Chemical Reviews, 104 (2004)
Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications
Tapan Kumar Giri
Acta Pharmaceutica Sinica. B, 2 (2012)
Effect of chitosan dissolved in different acids on its ability to control postharvest gray mold of table grape
Romanazzi G
Phytopathology, 99(9) (2009)
Zhilong Shi et al.
Biomaterials, 27(11), 2440-2449 (2005-12-13)
Although total joint replacement has become commonplace in recent years, bacterial infection remains a significant complication following this procedure. One approach to reduce the incidence of joint replacement infection is to add antimicrobial agents to the bone cement used to
Evaluation of the biological properties of soluble chitosan and chitosan microspheres
Carreno-Gomez, B
International Journal of Pharmaceutics, 148 (1997)
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