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904643

Sigma-Aldrich

Thiol functionalized gelatin

Synonyme(s) :

Functionalized gelatin, Gelatin thiol, Gelatin-SH• Gel-SH, SH functionalized gelatin, Thiol functionalized gelatin, Thiol gelatin, Thiolated gelatin

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1 G
88,40 €

88,40 €

Date d'expédition estimée le02 avril 2025

Devis pour commande en gros
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1 G
88,40 €

About This Item

Code UNSPSC :
12352105
Nomenclature NACRES :
NA.23

88,40 €

Date d'expédition estimée le02 avril 2025

Devis pour commande en gros

Description

NMR: Conforms to structure
Thiol content 150-350 μmol/g

Essai

150-350 μmol/g (Free Thiol Concentration by UVVI, UV-vis)

Forme

powder

Couleur

white to pale yellow

Température de stockage

−20°C

Application

Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Functionalized gelatin can be cross-linked with the formation of covalent bonds into highly crosslinked structures, such as hydrogels. Recent literature suggests that radical-mediated polymerized hydrogels may not be ideal for cell and protein encapsulation due to radical-mediated damage, hindered molecular transport, or altered cell-cell/cell-material interactions. Thiol-modified gelatin can be used to form hydrogels with multifunctional norbornene or allyl crosslinkers via thiol-ene click or Michael-addition reactions.
To improve solubility in water, heat to 40°C and stir for 10-15 minutes.

Attention

Material should be handled under nitrogen - air/oxygen & moisture are to be avoided.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCJ5413

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Gelatin from porcine skin medium gel strength, suitable for microbiology

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48722

Gelatin from porcine skin

Gélatine from cold water fish skin 40-50% in H2O

Sigma-Aldrich

G7765

Gélatine from cold water fish skin

Gelatin from bovine skin Type B

Sigma-Aldrich

G6650

Gelatin from bovine skin

Gelatin hydrogels formed by orthogonal thiol?norbornene photochemistry for cell encapsulation
Munoz Z, et al.
Biomaterials Science, 2, 1063-1072 (2014)
Vinh X Truong et al.
Biomacromolecules, 18(3), 757-766 (2017-02-15)
Swelling of hydrogels leads to a decrease in mechanical performance coupled with complications in solute diffusion. In addition, hydrogel swelling affects patient safety in biomedical applications such as compression of tissue and fluid blockage. A conventional strategy for suppressing swelling
Modular Cross-Linking of Gelatin-Based Thiol?Norbornene Hydrogels for in Vitro 3D Culture of Hepatocellular Carcinoma Cells
Greene T, et al
ACS biomaterials science & engineering, 1 (12), 1314?1323-1314?1323 (2015)

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Three-Dimensional Bioprinting for Tissue and Disease Modeling

Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.

Protocoles

KAPA SYBR® FAST One-Step qRT-PCR Kits FAQs

Frequently asked questions (FAQs) for KAPA SYBR® FAST One-Step qRT-PCR Kits.

Questions

1–3 sur 3 questions  

  1. Could I ask what gelatin is used for the modification? Is it typ A or type B, and is the origin bovine or porcin?

    1 réponse

    1. This product is prepared from a porcine Type A gelatin.

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  2. What is the expected bloom number for product 904643?

    1 réponse

    1. It is bloom 300.

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  3. How should it be dissolved? I tried to make a 50g/L PBS solution and left it in an incubator at 40 degrees overnight, but it did not dissolve.

    1 réponse

    1. Heat the gelatin solution to at least 50 °C while stirring continuously. The gelatin should dissolve to form a slightly hazy solution with no particulates. If the issue persists, please navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

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