748188

Bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex solution

in THF/toluene

• Formule linéaire : C₁₈H₃₆N₂Zn · xMgCl₂ · xLiCl
• Code UNSPSC : 12352103
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Composition: Bis(2,2,6,6-tetramethylpiperidinyl)zinc, ~12 wt. % ; LiCl, 2-4% ; MgCl₂, 6-9% ; THF/toluene, ca. 90:10 (solvent)
• Concentration: in THF/toluene
• Densité: 0.991 g/mL at 25 °C

Description

Description générale

Bis(2,2,6,6-tetramethylpiperidinyl)zinc,lithium chloride, magnesium chloride complex solution is an organozinc reagentextensively used in C-C bond forming,Negishi coupling, Michael additions, Cu(I)-promoted reactions, and electrophilic amination reactions.

Application

Bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex solution can be used as a base for the:

• Regioselective zincation of pyridines and related azines to synthesize zincated pyridines and azines.(1)
• Chemoselective direct zincation of arenes and heteroarenes to synthesize polyfunctional aryl and heteroaryl zinc reagents.
• Regioselective zincation of thiazoles to synthesize zincated thiazoles, which readily reacts with various electrophiles to form highly functionalized thiazoles.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H314,H335,H336,H351,H361d
• Conseils de prudence: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 3
• Organes cibles: Central nervous system, Respiratory system
• Risques supp: EUH014,EUH019
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 5.0 °F
• Point d'éclair (°C): -15 °C