734039
4-tert-Butyl-2,6-dimethylphenylsulfur trifluoride
Synonyme(s) :
Fluolead™
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About This Item
Formule empirique (notation de Hill):
C12H17F3S
Numéro CAS:
Poids moléculaire :
250.32
Numéro MDL:
Code UNSPSC :
12352002
ID de substance PubChem :
Nomenclature NACRES :
NA.22
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Forme
solid
Pf
62-68 °C
Chaîne SMILES
Cc1cc(cc(C)c1S(F)(F)F)C(C)(C)C
InChI
1S/C12H17F3S/c1-8-6-10(12(3,4)5)7-9(2)11(8)16(13,14)15/h6-7H,1-5H3
Clé InChI
VRTQPEYVMHATOA-UHFFFAOYSA-N
Description générale
4-tert-Butyl-2,6-dimethylphenylsulfur trifluoride is a thermally stable, easy-to-handle, versatile deoxofluorinating agent that also shows high stability on contact with water. It is a superior alternative to diethylaminosulfur trifluoride (DAST).
Application
Features:
Generally superior reactivity and selectivity to SF4 and easier and safer to handle.
Shown to promote nucleophilic deoxofluorination reactions and exhibits excellent thermal stability, up to 150 °C, therefore rendering it safely applicable in a variety of processes, including industrial scale production.
Novel fluorinating reagent applicable to a variety of chemical processes (Scheme 1).
Refer to the Datasheet for more information on Fluolead™: A Novel New Versatile Fluorinating Agent
- Tolerance of many functional groups
- Highly selective functionalization
- Highly efficient and broad reaction scope
- Mild reaction conditions
Generally superior reactivity and selectivity to SF4 and easier and safer to handle.
Shown to promote nucleophilic deoxofluorination reactions and exhibits excellent thermal stability, up to 150 °C, therefore rendering it safely applicable in a variety of processes, including industrial scale production.
Novel fluorinating reagent applicable to a variety of chemical processes (Scheme 1).
Refer to the Datasheet for more information on Fluolead™: A Novel New Versatile Fluorinating Agent
Informations légales
Fluolead is a trademark of UBE America, Inc.
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 3 Oral - Skin Corr. 1B
Risques supp
Code de la classe de stockage
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Kirk, K. L
Organic Process Research & Development, 12, 305-321 (2008)
Discovery of 4-tert-butyl-2, 6-dimethylphenylsulfur trifluoride as a deoxofluorinating agent with high thermal stability as well as unusual resistance to aqueous hydrolysis, and its diverse fluorination capabilities including deoxofluoro-arylsulfinylation with high stereoselectivity.
Umemoto T, et al.
Journal of the American Chemical Society, 132(51), 18199-18205 (2010)
Teruo Umemoto et al.
Journal of the American Chemical Society, 132(51), 18199-18205 (2010-12-04)
Versatile, safe, shelf-stable, and easy-to-handle fluorinating agents are strongly desired in both academic and industrial arenas, since fluorinated compounds have attracted considerable interest in many areas, such as drug discovery, due to the unique effects of fluorine atoms when incorporated
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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