279552
4-Chloro-3-ethylphenol
97%
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About This Item
Formule linéaire :
ClC6H3(C2H5)OH
Numéro CAS:
Poids moléculaire :
156.61
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352100
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Produits recommandés
Essai
97%
Forme
solid
Pf
45-50 °C (lit.)
Groupe fonctionnel
chloro
Chaîne SMILES
CCc1cc(O)ccc1Cl
InChI
1S/C8H9ClO/c1-2-6-5-7(10)3-4-8(6)9/h3-5,10H,2H2,1H3
Clé InChI
DVKVZPIRWWREJC-UHFFFAOYSA-N
Application
4-Chloro-3-ethylphenol is a ryanodine receptor antagonist and is commonly used as research tool and diagnostic reagent for malignant hyperthermia[1].
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
235.4 °F - closed cup
Point d'éclair (°C)
113 °C - closed cup
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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C Y Kwan et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 20(5), 385-390 (2000-05-20)
To study the spatial and temporal distribution of intracellular Ca2+ concentration in cultured bovine pulmonary artery endothelial (BPAE) cells. Cultured BPAE cells were loaded with Fura-2 and observed under an inverted microscope coupled to a microfluorimeter, which enables pixel-to-pixel ratio
A M Low et al.
British journal of pharmacology, 122(3), 504-510 (1997-11-14)
1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal cisternae and in a variety of non-excitable cell types. Its action on smooth muscle
M U Gerbershagen et al.
European journal of anaesthesiology, 19(2), 135-140 (2002-05-10)
The in vitro contracture test with halothane and caffeine is the current gold standard for diagnosis of malignant hyperthermia. This test has a sensitivity of 99.0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguishes
M U Gerbershagen et al.
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 39(2), 81-86 (2004-02-10)
The diagnosis of malignant hyperthermia is currently performed with the in-vitro contracture test (IVCT) with halothane and caffeine. This test has a sensitivity of 99.0 % but only a specificity of 93.6 %. A cumulative IVCT with 4-chloro-3-ethyl-phenole (CEP) has
Francisco H Andrade et al.
Investigative ophthalmology & visual science, 46(12), 4541-4547 (2005-11-24)
The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regulates [Ca2+]i and production of
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