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S4441

Sigma-Aldrich

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

Synonyme(s) :

1-Isothiocyanato-4-(methylsulfinyl)-butane

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About This Item

Formule empirique (notation de Hill):
C6H11NOS2
Numéro CAS:
4478-93-7
Poids moléculaire :
177.29
Numéro MDL:
MFCD00198068
Code UNSPSC :
12352200
ID de substance PubChem :
24724610
Nomenclature NACRES :
NA.77

product name

DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid

Source biologique

synthetic

Niveau de qualité

200

Pureté

≥90% (HPLC)

Forme

liquid

Solubilité

DMSO: soluble 40 mg/mL
H2O: insoluble

Compatibilité

for use with ABI 7500

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

Clé InChI

SUVMJBTUFCVSAD-UHFFFAOYSA-N

Application

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Actions biochimiques/physiologiques

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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β-caryophyllene, which is a constituent of many essential oils, has been known to be a selective agonist of the cannabinoid receptor type-2 and to exert cannabimimetic anti-inflammatory effects in animals. The effects of β-caryophyllene on macrophages have not been investigated
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A number of natural compounds with inhibitory effects on tumorigenesis have been identified from our diet. Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous
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Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of NRF2 activity. Here we utilise four members of the aldo-keto
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Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of vegetables induces enzymes of xenobiotic metabolism and thereby accelerates the metabolic disposal of xenobiotics. Induction of phase II detoxication
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