The solubility of H9377 has been tested at a concentration of 50 mg/ml in a mixture of 2 parts formic acid to 1 part water, equivalent to a 5% solution. While this may not represent the maximum solubility in the formic acid water mixture, it is the available data. The molecular weight of Hypoxanthine is 136.11 amu, and a 1M solution can be prepared by dissolving 136.11 grams in 1 liter of solvent, provided that there is a suitable solvent for dissolution. This amount can be scaled down to the desired volume. Aliquots should be stored at -20°C for up to 6 months.
H9377
Hypoxanthine
≥99.0%
Synonyme(s) :
6-Hydroxypurine
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1 G
63,00 €
5 G
129,00 €
25 G
195,00 €
100 G
523,00 €
About This Item
Formule empirique (notation de Hill) :
C5H4N4O
Numéro CAS:
Poids moléculaire :
136.11
Beilstein:
5811
Numéro CE :
Numéro MDL:
Code UNSPSC :
41106305
ID de substance PubChem :
Nomenclature NACRES :
NA.51
63,00 €
En stockDétails
Produits recommandés
Source biologique
synthetic (organic)
Niveau de qualité
Essai
≥99.0%
Forme
powder
Pf
>300 °C (lit.)
Solubilité
formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow
Chaîne SMILES
O=C1NC=Nc2nc[nH]c12
InChI
1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
Clé InChI
FDGQSTZJBFJUBT-UHFFFAOYSA-N
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Application
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Hypoxanthine has been used:
- to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia[1]
- as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)[2]
- as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval[3]
Actions biochimiques/physiologiques
Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position.[4] It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.[5]
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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