Journal of colloid and interface science, 459, 250-256 (2015-08-25)
Mixed solutions of cationic and anionic surfactants show considerable synergism in their wetting behaviour, but their spreading is affected considerably by the phase separation processes. The valuable information about wetting properties of synergetic mixtures can be obtained by using mixtures
ACS chemical neuroscience, 6(8), 1487-1501 (2015-07-15)
In vivo microdialysis is widely used to investigate how neurotransmitter levels in the brain respond to biologically relevant challenges. Here, we combined recent improvements in the temporal resolution of online sampling and analysis for serotonin with a brief high-K(+) stimulus
Journal of medicinal chemistry, 52(14), 4338-4344 (2009-06-19)
The hydrophobic pocket within the coiled coil domain of HIV-1 gp41 is considered to be a hot-spot suitable for small molecule intervention of fusion, although so far it has yielded only microM inhibitors. Previous peptide studies have identified specific hydrophobic
Journal of pharmaceutical sciences, 103(7), 2157-2165 (2014-05-16)
The major obstacle to glioblastoma pharmacological therapy is the overcoming of the blood-brain barrier (BBB). In literature, several strategies have been proposed to overcome the BBB: in this experimental work, solid lipid nanoparticles (SLN), prepared according to fatty acid coacervation
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity is acutely inhibited. Chronically high ACh
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
