MAP2K2
mitogen-activated protein kinase kinase 2
Synonymes:
CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Espèce(s):
Human MAP2K2 (5605), Mouse Map2k2 (26396), Rat Map2k2 (58960), chicken MAP2K2 (396349), dog MAP2K2 (611939), cow MAP2K2 (510434), sheep MAP2K2 (101113846), naked mole-rat Map2k2 (101707562), domestic guinea pig Map2k2 (100728923)
ID UniProtKB:
ID du gène:
- Human(5605) Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(26396) mitogen-activated protein kinase kinase 2
- Rat(58960) mitogen activated protein kinase kinase 2
- chicken(396349) mitogen-activated protein kinase kinase 2
- dog(611939) mitogen-activated protein kinase kinase 2
- cow(510434) mitogen-activated protein kinase kinase 2
- sheep(101113846) mitogen-activated protein kinase kinase 2
- naked mole-rat(101707562) mitogen-activated protein kinase kinase 2
- domestic guinea pig(100728923) mitogen-activated protein kinase kinase 2
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-MEK2 Antibody, clone 1J7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, canine, feline, horse, human, monkey
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MAP2K2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-MAP2K2 (pThr394) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-MEK2 (pThr394) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MAP2K2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
MEK2, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human