89866

p-Toluenesulfonic acid monohydrate

analytical standard

• Linear Formula: CH₃C₆H₄SO₃H · H₂O
• CAS Number: 6192-52-5
• Molecular Weight: 190.22
• Beilstein: 3568023
• MDL number: MFCD00142137
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• vapor density: 5.9 (vs air)
• Assay: 95.0-105.0% (anhydrous basis, T)
• form: solid
• shelf life: limited shelf life, expiry date on the label
• impurities: 9.5-11.5% water
• mp: 103-106 °C (lit.)
• SMILES string: [H]O[H].Cc1ccc(cc1)S(O)(=O)=O
• InChI: 1S/C7H8O3S.H2O/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H2
• InChI key: KJIFKLIQANRMOU-UHFFFAOYSA-N

Description

Application

• p-Toluenesulfonic acid monohydrate in organic synthesis: p-Toluenesulfonic acid monohydrate serves as a powerful catalyst in various organic syntheses, including the synthesis of bioactive molecules. It facilitates a range of reactions such as esterifications and acylations crucial for developing pharmaceutical compounds. The use of this catalyst is integral to enhancing reaction rates and improving yield efficiencies in medicinal chemistry (Kim et al., 2022).


• Pharmaceutical synthesis reagent: As a versatile reagent, p-Toluenesulfonic acid monohydrate is utilized in pharmaceutical research for the synthesis of complex drug molecules. Its role in improving the solubility and stability of pharmaceutical agents underscores its importance in drug development processes, particularly in the formulation of active pharmaceutical ingredients (Huang et al., 2020).


• Antioxidant research compound: Researchers use p-Toluenesulfonic acid monohydrate to study antioxidant properties in various chemical systems. Its application in determining the stability and effectiveness of antioxidants helps in the development of new therapeutic agents that combat oxidative stress and related diseases (Fidan et al., 2018).


• Tosic acid hydrate in biochemistry: In biochemistry, p-Toluenesulfonic acid monohydrate is used to study enzyme catalysis and reaction mechanisms. Its application helps in understanding the biochemical pathways where acid catalysis is crucial, providing insights into enzyme behavior and kinetics in biological systems (Kwiecień et al., 2016).


• Catalysis in pharmaceutical research: p-Toluenesulfonic acid monohydrate is extensively used in catalysis within pharmaceutical research to enhance the efficiency of chemical reactions. This application is critical for the rapid and cost-effective synthesis of new drug candidates, highlighting its pivotal role in accelerating drug discovery and development (Kim et al., 2022).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable