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T0682

Sigma-Aldrich

Sodium taurohyodeoxycholate hydrate

≥98%

Synonym(s):

Taurohyodeoxycholic acid sodium salt hydrate

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About This Item

Linear Formula:
C26H44NO6SNa · xH2O
CAS Number:
38411-85-7
Molecular Weight:
521.69 (anhydrous basis)
MDL number:
MFCD09263185
UNSPSC Code:
12161900
PubChem Substance ID:
24899908
NACRES:
NA.25

description

anionic

Assay

≥98%

mol wt

521.69 g/mol (anhydrous basis)

application(s)

detection

SMILES string

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-;;/m1../s1

InChI key

MJKUJELEPWZEGU-IGEKTTBWSA-M

Related Categories

General description

Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.

Application

Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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P Loria et al.
The Italian journal of gastroenterology, 28(7), 391-392 (1996-09-01)
Taurohyodeoxycholic acid and tauroursodeoxycholic acid were infused intraduodenally at a rate of 0.8 g/h for three hours in 3 cholecystectomized T-tube patients. Biliary lipid secretion and bile acid composition were evaluated before and after replacement of the endogenous bile acid
Angela Mally et al.
Molecular nutrition & food research, 54(11), 1556-1567 (2010-06-12)
Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as
F Feletti et al.
Arzneimittel-Forschung, 43(8), 888-893 (1993-08-01)
Fifty-two-week oral toxicity and 24-week intramuscular toxicity of a new synthetized biliary acid, taurohyodeoxycholic acid (Io, Praxis, CAS 2958-04-5) were investigated in dogs. Taurohyodeoxycholic acid was orally administered at dose levels up to 500 mg/kg/d and i.m. administered at dose
A S Tripodi et al.
Arzneimittel-Forschung, 43(8), 897-903 (1993-08-01)
The mutagenicity of a new biliary acid, taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), was assayed by using 5 different tests. The Ames test (reverse mutation assay on Salmonella typhimurium) and the DNA damage and repair test (in Saccharomyces cerevisiae)
K J Van Erpecum et al.
European journal of clinical investigation, 26(7), 602-608 (1996-07-01)
Precipitation of cholesterol crystals is an essential step in gallstone formation. In the present study we found much faster and more extensive precipitation of various cholesterol crystal shapes in whole model biles containing the hydrophobic bile salt taurodeoxycholate than in
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