SML4025

Drp1 inhibitor, SC9

≥98% (HPLC)

• Synonym(s): N-[6-Amino-1,2,3,4-tetrahydro-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-methylacetamide, SC9
• Empirical Formula (Hill Notation): C₂₁H₂₂N₈O₃S
• CAS Number: 851471-44-8
• Molecular Weight: 466.52
• MDL number: MFCD06382355
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: CC1=NC2=NC(SCC(N(C(C(N3)=O)=C(N)N(CC4=CC=CC=C4)C3=O)C)=O)=NN2C(C)=C1

Description

Biochem/physiol Actions

Cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1).
Drp1 inhibitor SC9 is a cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1) that binds to a switch I-adjacent grove (SWAG) on Drp1. SC9 inhibits Drp1-Fis1 interaction in cells and eases the burden of Drp1-mediated pathologies such as LPS-induced mitochondrial dysfunction. It rescues mice from LPS-induced endotoxemia.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable