SML3106

7ACC2

≥98% (HPLC)

• Synonym(s): 7-(N-Benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid, 7-ACC2, 7-Aminocarboxycoumarin 2, 7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid, 7-[Methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
• Empirical Formula (Hill Notation): C₁₈H₁₅NO₄
• CAS Number: 1472624-85-3
• Molecular Weight: 309.32
• MDL number: MFCD28167835
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(O)C1=CC2=C(C=C(C=C2)N(C)CC3=CC=CC=C3)OC1=O

Description

Biochem/physiol Actions

7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable