SML2560

OB-1

≥98% (HPLC)

• Synonym(s): Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
• Empirical Formula (Hill Notation): C₂₁H₁₇N₃O₆
• CAS Number: 300803-69-4
• Molecular Weight: 407.38
• MDL number: MFCD01462999
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to very dark brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C
• InChI key: UJHGRDVYTTVJFD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Inhibitor of Stomatin-like protein-3 (STOML3) oligomerization

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable