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SML2336

Sigma-Aldrich

Sk052-145-2

≥97% (HPLC)

Synonym(s):

4-(Cyclopentyloxy)-5-methoxy-2-nitro-N-(5-(pentan-3-yl)-1,3,4-thiadiazol-2-yl)benzamide, Lipoprotein signal peptidase inhibitor, Lsp inhibitor

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5 MG
€80.50
25 MG
€227.50

€80.50

Estimated to ship onApril 17, 2025

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5 MG
€80.50
25 MG
€227.50

About This Item

Empirical Formula (Hill Notation):
C20H26N4O5S
CAS Number:
2260687-53-2
Molecular Weight:
434.51
UNSPSC Code:
12352200
NACRES:
NA.77

€80.50

Estimated to ship onApril 17, 2025

Request a Bulk Order

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=NN=C(C(CC)CC)S1)C2=CC(OC)=C(OC3CCCC3)C=C2[N+]([O-])=O

InChI

1S/C20H26N4O5S/c1-4-12(5-2)19-22-23-20(30-19)21-18(25)14-10-16(28-3)17(11-15(14)24(26)27)29-13-8-6-7-9-13/h10-13H,4-9H2,1-3H3,(H,21,23,25)

InChI key

QRUAZOLDUDHNBK-UHFFFAOYSA-N

Biochem/physiol Actions

Sk052-145-2 is a potent and selective inhibitor of bacterial Lipoprotein signal peptidase (Lsp). Sk052-145-2 potently inhibits growth of E. Coli in a presence of polymyxin B nonapeptide (PMBN).
potent and selective inhibitor of bacterial Lipoprotein signal peptidase (Lsp)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Seiya Kitamura et al.
Cell chemical biology, 25(3), 301-308 (2018-01-18)
As resistance to antibiotics increases, the exploration of new targets and strategies to combat pathogenic bacteria becomes more urgent. Ideal protein targets are required for viability across many species, are unique to prokaryotes to limit effects on the host, and have

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