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SML1894

Sigma-Aldrich

SYP-5

≥98% (HPLC)

Synonym(s):

(2E)-1-(5-Hydroxy-2-2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-2-propen-1-one, (E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thio-phen-2-yl)prop-2-en-1-one

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5 MG
€79.30

€79.30


Estimated to ship onApril 11, 2025


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5 MG
€79.30

About This Item

Empirical Formula (Hill Notation):
C18H16O3S
CAS Number:
Molecular Weight:
312.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

€79.30


Estimated to ship onApril 11, 2025


Request a Bulk Order

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(C=CC(C)(C)O2)C2=CC=C1C(/C=C/C3=CC=CS3)=O

InChI key

OMVURDVBYIJCOI-FNORWQNLSA-N

Biochem/physiol Actions

SYP-5 is potent and selective inhibitor of HIF-1 activity that decreases HIF-1α and HIF-1β protein levels under hypoxic condition. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis.
SYP-5 is potent and selective inhibitor of HIF-1 activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Li-Hui Wang et al.
European journal of pharmacology, 791, 560-568 (2016-10-30)
Hypoxia-inducible factor-1 (HIF-1) plays an essential role in carcinogenesis. The overexpression of HIF-1 induced by hypoxia is closely associated with metastasis, poor prognosis and high mortality. In this study, a novel HIF-1 inhibitor SYP-5 was first observed by the luciferase

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