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SML1616

Sigma-Aldrich

ICA-069673

≥98% (HPLC)

Synonym(s):

ICA 069673, N-(2-Chloro-5-pyrimidinyl)-3,4-difluoro-benzamide

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5 MG
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About This Item

Empirical Formula (Hill Notation):
C11H6ClF2N3O
CAS Number:
582323-16-8
Molecular Weight:
269.63
MDL number:
MFCD20926351
UNSPSC Code:
12352200
PubChem Substance ID:
329825502
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2

InChI

1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)

InChI key

IIBSHMFXVWTQSJ-UHFFFAOYSA-N

Biochem/physiol Actions

ICA-069673 has higher selectivity towards KV7.2/KV7.3 heterodimeric channels than KV7.3/KV7.5 channels. ICA-069673 is considered as a part of gating modifiers.[1]
ICA-069673 is an orally active, potent and selective KV7.2/KV7.3 (KCNQ2/Q3) channel opener that is active in rodent epilepsy models.
ICA-069673 is an orally active, potent and selective KV7.2/KV7.3 (KCNQ2/Q3) channel opener.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000414313
0000207782
0000207782
0000177135
0000177135

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The novel KV7. 2/KV7. 3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility.
Provence A, et al.
Journal of Pharmacology and Experimental Therapeutics, 354(3), 290-301 (2015)

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