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SML0810

Sigma-Aldrich

MHY1485

≥95% (HPLC)

Synonym(s):

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

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About This Item

Empirical Formula (Hill Notation):
C17H21N7O4
CAS Number:
326914-06-1
Molecular Weight:
387.39
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

InChI key

MSSXBKQZZINCRI-UHFFFAOYSA-N

Application

MHY1485 has been used:
  • to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
  • to inhibit autophagy
  • as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cross regulation between mTOR signaling and O-GlcNAcylation
Very N, et al.
Journal of Bioenergetics and Biomembranes, 50(3), 213-222 (2018)
Duc-Vinh Pham et al.
Journal of experimental & clinical cancer research : CR, 41(1), 9-9 (2022-01-07)
Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been
Rui Ma et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 54(12), e11183-e11183 (2021-10-21)
Due to the high mortality and rapid disease progression, ovarian cancer remains one of the most common malignancies threatening the health of women. The present study was conducted to explore the anticancer effects and the underlying mechanisms of poricoic acid
Xinqi Zhuang et al.
International immunopharmacology, 81, 106287-106287 (2020-02-15)
Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. Hydrogen has emerged as a promising therapeutic agent to alleviate SAE. The mechanism, however, remains unclear. This research aimed to determine whether
Nan Wu et al.
Journal of cellular and molecular medicine, 23(2), 1354-1362 (2018-11-30)
The RNA helicase p68 (DDX5), a key player in RNA metabolism, belongs to the DEAD box family and is involved in the development of colorectal cancer. Here, we found both DDX5 and O-GlcNAcylation are up-regulated in colorectal cancer. In addition
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