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SML0482

Sigma-Aldrich

3CAI

≥95% (HPLC)

Synonym(s):

2-Chloro-1-(1H-indol-3-yl)ethanone, 3-Chloroacetyl-indole, Chloromethyl indol-3-yl ketone

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About This Item

Empirical Formula (Hill Notation):
C10H8ClNO
CAS Number:
28755-03-5
Molecular Weight:
193.63
MDL number:
MFCD00464796
UNSPSC Code:
12352200
PubChem Substance ID:
329825433
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

yellow to brown

solubility

DMSO: 5 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(CCl)C1=CNC2=C1C=CC=C2

InChI

1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2

InChI key

LLZQFAXTCYDVTR-UHFFFAOYSA-N

Biochem/physiol Actions

3CAI is a potent and specific allosteric inhibitor of Akt1 and Akt2.
3CAI is an orally active, potent and specific allosteric inhibitor of Akt1 and Akt2 that directly binds to Ak1 and Akt2 in an ATP noncompetitive manner.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
112M4703V

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Ji-Eun Kim et al.
Cell death & disease, 9(5), 546-546 (2018-05-12)
Recently, we have reported that heat shock protein B1 (HSPB1) and purinergic receptor P2X7 (P2RX7) are involved in astroglial autophagy (clasmatodendrosis), following status epilepticus (SE). However, the underlying mechanisms of astroglial autophagy have not been completely established. In the present
[Photometric determination of 3-chloroacetyl indole in the air].
E I Kosterina et al.
Gigiena i sanitariia, (2)(2), 48-49 (1988-02-01)

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