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SML0431

Sigma-Aldrich

PQ1 succinate

≥98% (HPLC)

Synonym(s):

N1-[6-Methoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,3-propanediamine butanedioic acid salt, PQ1 succinic acid salt

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About This Item

Empirical Formula (Hill Notation):
C25H28F3N3O6
CAS Number:
955995-51-4
Molecular Weight:
523.50
MDL number:
MFCD22666397
UNSPSC Code:
12352202
PubChem Substance ID:
329824715
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to brown

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

OC(=O)CCC(O)=O.COc1cc(NCCCN)c2nccc(C)c2c1Oc3cccc(c3)C(F)(F)F

InChI

1S/C21H22F3N3O2.C4H6O4/c1-13-7-10-27-19-16(26-9-4-8-25)12-17(28-2)20(18(13)19)29-15-6-3-5-14(11-15)21(22,23)24;5-3(6)1-2-4(7)8/h3,5-7,10-12,26H,4,8-9,25H2,1-2H3;1-2H2,(H,5,6)(H,7,8)

InChI key

XFEIMRMBZQODRY-UHFFFAOYSA-N

Biochem/physiol Actions

PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. Treatment of the breast cancer cell line T47D with 200 nM PQ1 induces a 30% increase in gap junctional intercellularcommunication (GJIC) and a 90% decrease in cell growth, with no effect on normal breast epithelial cells.
PQ1 is a Gap Junction ctivator; connexin 43 binder.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
072M4618V

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Ying Ding et al.
Journal of cancer science & therapy, 4(11), 371-378 (2012-11-01)
Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitation of cisplatin in cancer therapeutics. Recent studies showed
Ying Ding et al.
Anti-cancer drugs, 23(9), 897-905 (2012-05-10)
Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules. The loss of gap junctional intercellular communication (GJIC) is one of the important hallmarks of cancer. Restoration of GJIC is related to the reduction of tumorigenesis
Ying Ding et al.
Apoptosis : an international journal on programmed cell death, 18(9), 1071-1082 (2013-05-17)
Apoptosis, a programmed cell death, is an important control mechanism of cell homeostasis. Deficiency in apoptosis is one of the key features of cancer cells, allowing cells to escape from death. Activation of apoptotic signaling pathway has been a target

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