SAB4200179

Anti-Importin 5 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-IPO5
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~123 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 2.5-5.0 μg using lysates of human HEK-293 cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293 cells overexpressing human Importin 5.; western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
• UniProt accession no.: O00410
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IPO5(3843) ; mouse ... Ipo5(70572) ; rat ... Ipo5(306182)

Description

General description

In human cells, there are more than 20 members of the importins/exportins family. Importin-5 (IPO5) belongs to the importin-β superfamily and is mapped to human chromosome 13q32.2.

Application

Anti-Importin 5 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins are regulated by the Ran G protein. Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable