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SAB2900401

Sigma-Aldrich

Anti-XAF1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

XAF 1, XAF-1, XAF1, XIAP associated factor-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

UniProt accession no.

Q6GPH4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... XAF1(54739)

General description

XIAP associated factor 1 (XAF1) is a cytokine-regulated protein expressed in the cytoplasm. It contains a tumor necrosis factor receptor-associated factor (TRAF) domain. The gene encoding XAF1 is localized on human chromosome 17p13.1.

Immunogen

Synthetic peptide from human XAF1/XIAP-assoicated factor 1

Application

Anti-XAF1 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

XIAP associated factor 1 (XAF1) is an inhibitor of tumor growth. It has a role in restoring X-linked inhibitor of apoptosis (XIAP)-suppressed caspase activity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability.
Lin B
Febs Letters (2016)
[XAF1 inhibits cell proliferation and induces apoptosis in human lung adenocarcinoma cell line A549 in vitro].
Chen D
Zhongguo Fei ai za Zhi = Chinese Journal of Lung Cancer (2014)
XAF1 is frequently methylated in human esophageal cancer.
World Journal of Gastroenterology (2012)
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
Andrea Lunardi
Nature Genetics (2013)
Andrea Lunardi et al.
Nature genetics, 45(7), 747-755 (2013-06-04)
Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a

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